| Product Name | A11 |
|---|---|
| Description |
A11 is a peptide derived from amino acid residues 20-30 of the ANXA1 N-terminus fused to the cell penetrating peptide CPP. A11 blocks ANXA1 competition with the E3 ubiquitin ligase Cbl for binding EphA2, enhancing Cbl-mediated EphA2 ubiquitination and degradation, and reducing the oncogenic mechanism of the ANXA1– EphA2 interaction in nasopharyngeal carcinoma (NPC). A11 can suppress NPC cell growth in vitro and in vivo. |
| Synonyms | ANXA1-derived 11 amino acid-long peptide |
| Molecular Weight | 2767.19 Da |
| Target | Protein-protein interactions |
| Amino Acid Sequence | YGRKKRRQRRREYVQTVKSSKG |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Feng et al (2020) ANXA1 Binds and Stabilizes EphA2 to Promote Nasopharyngeal Carcinoma Growth and Metastasis. Cancer Res. 80(20) 4386 PMID: 32737118 Related categoriesAll cell penetrating peptides >All protein-protein interaction modulators >All cancer research categories >All ubiquitin-proteasome system categories > |
| Supplier | Isca Biochemicals Limited |
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