| Product Name | A20FMDV2 |
|---|---|
| Description | A20FMDV2 is a peptide derived from the foot-and-mouth disease virus with a high affinity and selectivity for the alpha-v beta-6 (αvβ6) arginyl-glycinyl-aspartic acid (RGD)-binding integrin, inhibiting alphavbeta6-ligand binding with a IC50 of 3 nmol/L, an activity 1,000-fold more selective for alphavbeta6 than for other RGD-directed integrins (alphavbeta3, alphavbeta5, and alpha5beta1). |
| Synonyms | 932699-03-1, A20FMDV2, H-NAVPNLRGDLQVLAQKVART-NH2, IG-010, IG010, NAVPNLRGDLQVLAQKVART, alpha-v beta-6, arginyl-glycinyl-aspartic acid, foot-and-mouth, αv β6 |
| Molecular Weight | 2162.5 Da |
| Target | Integrin receptors,Antivirals |
| Amino Acid Sequence | NAVPNLRGDLQVLAQKVART-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Storage | We recommend storage desiccated, frozen and in the dark |
| Notes | Modifications: C terminal amide |
| References |
Hausner et al (2007) Use of a Peptide Derived from Foot-and-Mouth Disease Virus for the Noninvasive Imaging of Human Cancer: Generation and Evaluation of 4-[18F]Fluorobenzoyl A20FMDV2 for In vivo Imaging of Integrin αvβ6 Expression with Positron Emission Tomography. Cancer Res. 67(16) 7833 PMID: 17699789Slack et al (2016) Pharmacological Characterization of the αvβ6 Integrin Binding and Internalization Kinetics of the Foot-and-Mouth Disease Virus Derived Peptide A20FMDV2. Pharmacology 97(3-4) 114 PMID: 26734728 Related areasAll peptides >All antivirals >All integrin receptor modulators > |
| Supplier | Isca Biochemicals Limited |
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