| Product Name | AC 187 |
|---|---|
| Description |
AC 187 is an orally active, amylin receptor antagonist with an IC50 of 0.48 nM that displays 38 and 400 fold selectivity over calcitonin and CGRP receptors respectively. Blockade of amylin with AC 187 increases glucagon concentration, accelerates gastric emptying of liquids, and results in an exaggerated post-challenge glycemia. AC 187 alone increases feeding when infused into the area postrema. |
| Synonyms | 151804-77-2, AC 187, Ac-VLGKLSQELHKLQTYPRTNTGSNTY-NH2, CG 060, CG-060, CG060 |
| Molecular Weight | 2890.25 Da |
| Target | Calcitonin and related receptors |
| Amino Acid Sequence | Ac-VLGKLSQELHKLQTYPRTNTGSNTY-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 151804-77-2 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: N-terminal Ac, C-terminal amide |
| References |
Rushing (2001) Inhibition of central amylin signaling increases food intake and body adiposity in rats. Endocrinolog 142(11) 5035 PMID: 11606473Mollet (2004) Infusion of the amylin antagonist AC 187 into the area postrema increases food intake in rats. Physiol Behav. 81(1) 149 PMID: 15059694Gedulin et al (2006) Role of endogenous amylin in glucagon secretion and gastric emptying in rats demonstrated with the selective antagonist, AC187. Regul.Pept. 137 121 PMID: 16914214 Related areasAll peptides >All calcitonin and related receptors >All appetite regulation research categories > |
| Supplier | Isca Biochemicals Limited |
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