| Product Name | ACD Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to ACD |
| Synonyms | Acd antibody; ACD_HUMAN antibody; Adrenocortical dysplasia homolog antibody; Adrenocortical dysplasia protein homolog antibody; PIP1 antibody; POT1 and TIN2 organizing protein antibody; POT1 and TIN2-interacting protein antibody; TIN2 interacting protein 1 antibody; TINT1 antibody; TPP1 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Adrenocortical dysplasia protein homolog protein (328-497AA) |
| Isotype | IgG |
| Target | ACD |
| Reactivity | Human, Mouse |
| Applications | ELISA, WB |
| Form | Liquid |
| Diluent Buffer | Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Uniprot | Q96AP0 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis. |
| Supplier | Cusabio |
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