| Product Name | [Ala11, D-Leu15]-Orexin B |
|---|---|
| Description | [Ala11,D-Leu15]-Orexin B is a highly potent and selective OX2 receptor agonist with 400-fold selectivity for OX2 over OX1 receptors, possessing EC50 values of 0.13 and 52 nM for human OX2 and OX1 receptors respectively. [Ala11,D-Leu15]-Orexin B increases social novelty seeking and can decrease anxious and depressive behaviour in animal models. |
| Synonyms | [Ala(11), D-Leu(15)]orexin-B, [Ala11, d-Leu15]-OrxB, Selective OX2R agonist |
| Molecular Weight | 2857.28 Da |
| Target | Orexin receptors |
| Amino Acid Sequence | RSGPPGLQGRAQRLLQASGNHAAGILTM-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 532932-99-3 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: C-terminal amide |
| References |
Asahi et al (2003) Development of an orexin-2 receptor selective agonist, [Ala11D-Leu15]orexin-B. Bioorg.Med.Chem.Lett. 13 111 PMID: 12467628Borgland et al (2008), Orexin B/hypocretin 2 increases glutamatergic transmission to ventral tegmental area neurons. European J. Neuroscience 28 1545 PMID: 18793323Staton et al (2018) Orexin 2 receptor stimulation enhances resilience, while orexin 2 inhibition promotes susceptibility, to social stress, anxiety and depression, Neuropharmacology 143 79 PMID: 30240784 Related areas All peptides >All orexin receptor modulators >All neuroscience categories >All appetite regulation categories > |
| Supplier | Isca Biochemicals Limited |
All Research Products are sold for laboratory RESEARCH USE ONLY and ARE NOT TO BE USED FOR HUMAN OR ANIMAL THERAPEUTIC OR DIAGNOSTIC APPLICATIONS. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. ARP American Research Products, Inc. does not submit its products for regulatory review by any government body or other organization, and we do not validate them for clinical, therapeutic or diagnostic use, or for safety and effectiveness. You are solely responsible for making sure that the way you use the products complies with applicable laws, regulations and governmental policies and for obtaining all necessary approvals, intellectual property rights, licenses and permissions that you may need related to your use. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process. ARP American Research Products, Inc. disclaims any and all representations or warranties of any kind whatsoever, express or implied, including without limitation any implied warranties of merchantability or fitness for a particular purpose, of non-infringement, or regarding results obtained through the use of any product, whether arising from a statute or otherwise in law or from a course of performance, dealing or usage of trade.
