| Product Name | Anti-Adeno-associated virus (AAV), VP 1 |
|---|---|
| Description | Adeno-associated virus (AAV) is a small virus which infects humans and some other primate species. AAV is not currently known to cause disease and consequently the virus causes a very mild immune response. Gene therapy vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell. These features make AAV a very attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models. Mouse Monoclonal Antibody to Adeno-associated virus (AAV), VP 1. A1 reacts with VP1 of adeno-associated virus. A1 reacts with VP1 of AAV-2; weak cross-reaction with serotypes 1, 3, 4, 5, 6. In immunoprecipitation, an occasional reaction with a non-AAV-derived protein is found. |
| Synonyms | AAV2 |
| Clone | A1 |
| Immunogen | Adeno-associated virus capsid proteins and virus particles |
| Isotype | IgG2a |
| Specificity | Epitope mapping experiments (Wobus et al., see below) identified aa123 to aa131 of VP1 capsid protein as the specific binding region. In immunoprecipitation, an occasional reaction with a non-AAV-derived protein is found |
| Reactivity | Human, Primate |
| Applications | ELISA, IF, IHC, IP, WB |
| Form | Purified (Protein A), in PBS containing 1% BSA and 0.1% sodium-azide |
| Storage | 2-8C for immediate use, or at -2°C (aliquot) |
| References | Wistuba, A. et al.(1997) J. of Virology 71: 1341-1352Wobus,CE. et al. (2000) J. Virol 74 (19): 9281-9292 |
| Background | Adeno-associated virus (AAV) is a small virus which infects humans and some other primate species. AAV is not currently known to cause disease and consequently the virus causes a very mild immune response. Gene therapy vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell. These features make AAV a very attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models |
| Supplier | ARP |
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