Anti-AFP (Alpha Fetoprotein) (Hepatocellular/Germ Cell Tumor Marker), Monoclonal Antibody
| Product Name | Anti-AFP (Alpha Fetoprotein) (Hepatocellular/Germ Cell Tumor Marker), Monoclonal Antibody |
|---|---|
| Description | It recognizes an oncofetal glycoprotein with a single chain of 70kDa, which is identified as alpha fetoprotein (AFP) (ISOBM TD-2 workshop). This monoclonal antibody is highly specific to AFP and shows no cross-reaction with other oncofetal antigens or serum albumin. AFP is normally synthesized in the liver, intestinal tract, and yolk sac of the fetus. Antibody to AFP has been shown to be useful in detecting hepatocellular carcinomas (HCC) and germ cell neoplasms, especially yolk sac tumors. |
| Synonyms | Alpha fetoglobulin, FETA, HPAFP |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | C2 |
| Immunogen | Alpha fetoprotein (AFP) purified from serum of a hepatoma patient |
| Isotype | IgG1, kappa |
| Reactivity | Canine, Human, Mouse, Rat |
| Applications | FC, IF, IHC |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 174 |
| Uniprot | P02771 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Tsung K., et al.Milunsky A., Alpert E. Derivation and characterization of a monoclonal hybridoma antibody specific for human alpha-fetoprotein. J. Immunol. Methods 39: 363-368, (1980)Michell B., Fiebach H., Karsten U., Goussev A.I., Yazova A.K., Knopp J. Monoclonal antibodies to different epitopes of human alpha-fetoprotein (AFP). Eur. J. Cancer Clin. Oncol. 19:1239-1246, (1983).Yazova A.K., Goussev A.I., Poltorania V.S., Yakimenko E.F., Human alpha- fetoprotein epitopes as revealed by monoclonal antibodies. Immunol. Lett. 25: 325-330, (1990).Nustad K., Paus E., Kierulf B., Bormer O.P. Specificity and affinity of 30 monoclonal antibodies against alpha-fetoprotein. Tumor Biol 19: 293 -300, (1998).Yakimenko E.F., Karamova E.R., Goussev A.I., Hilgers J., Abelev G.I., Yazova A.K.: Epitope mapping of human alpha-fetoprotein. Tumor Biol 19: 301309, (1998) |
| Supplier | ARP |
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