Anti-CD35 / CR1 (Follicular Dendritic Cell Marker), Monoclonal Antibody
| Product Name | Anti-CD35 / CR1 (Follicular Dendritic Cell Marker), Monoclonal Antibody |
|---|---|
| Description | Recognizes a protein of 210-220kDa, which is identified as the complement receptor 1 (CR1)/CD35. This monoclonal antibody is specific for a site in CR1 that is distal from the C3b-binding site, so that it is unable to block CR1 activity. This monoclonal antibody is highly specific to CR1 and shows no cross-reaction with CR2. The primary function of CR1 is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. The Knops blood group system is a system of antigens located on this protein. Follicular dendritic cells (FDC) are restricted to the B-cell regions of secondary lymphoid follicles. They are CD21+/CD35+/CD1a-. This monoclonal antibody labels follicular dendritic cells and follicular dendritic cell sarcoma. |
| Synonyms | C3 binding protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | E11 |
| Immunogen | Intact human monocytes |
| Isotype | IgG1, kappa |
| Reactivity | Human, Primate |
| Applications | FC, IF, IHC |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 1378 |
| Uniprot | P17927 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Hogg N, et. al. European Journal of Immunology, 1984, 14:236-43 |
| Supplier | ARP |
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