| Product Name | Anti-CD48 (Pan Leukocyte Marker), Monoclonal Antibody |
|---|---|
| Description | Reacts with human CD48, a 45kDa glycosyl phophatidyl-inositol (GPI)-anchored cell surface protein. CD48 is strongly expressed on lymphocytes and monocytes and weakly on granulocytes but is absent on platelets, fibroblasts, epithelium and endothelium. CD48 is one of marker for detecting the defects of GPI anchoring structure on the patients with paroxysmal nocturnal hemoglobulinuria (PNH) and serves as a low affinity ligand for CD2. |
| Synonyms | B-cell activation marker, B-lymphocyte activation marker BLAST-1, BCM1 surface antigen, BLAST1, CD48 antigen (B cell membrane protein), Signaling lymphocytic activation molecule 2 (SLAMF2), SLAM family member 2 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 156-4H9 |
| Immunogen | Human CD48 protein |
| Isotype | IgG1, kappa |
| Reactivity | Human |
| Applications | FA, FC, IF |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 962 |
| Uniprot | P09326 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Kishimoto T. et al., eds. Leukocyte Typing VI, p509-514, Garland Publishing, Inc, New York and London, 1997. Yokoyama S et al. Expression of the Blast-1 activation/adhesion molecule and its identification as CD48. J Immunol 1991, 146(7):2192-2200.Kwong YL et al. Flow cytometric measurement of glycosylphosphatidyl-inositol-linked surface proteins on blood cells of patients with paroxysmal nocturnal hemoglobinuria. Am J Clin Pathol 1994, 102(1):30-35Sandrin MS et al. CD48 is a low affinity ligand for human CD2.J Immunol 1993, 151(9):4606-4613.Vaughan HA et al. The isolation of cDNA clones for CD48. Immunogenetics 1991, 33(2):113-117.Vaughan HA et al. Hu Ly-M3--a human leukocyte antigen. Transplantation 1983, 36(4):446-450 |
| Supplier | ARP |
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