Anti-CD70 / TNFSF7 (Activated T- & B-Lymphocyte Marker), Monoclonal Antibody
| Product Name | Anti-CD70 / TNFSF7 (Activated T- & B-Lymphocyte Marker), Monoclonal Antibody |
|---|---|
| Description | It recognizes a protein of 30kDa, identified as CD70. It is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T- and B-lymphocytes. It induces proliferation of co-stimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. This monoclonal antibody blocks the interaction between CD27 and CD70, and has been shown to_inhibit T cell proliferation induced by dendritic cells. |
| Synonyms | CD27 ligand (CD27L), CD27LG, Ki24, Surface antigen CD70, Tumor necrosis factor (ligand) superfamily, member 7 (TNFSF7) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | BU69 |
| Immunogen | Human WM-1 (Waldenstrom s macroglobulinemia) cell line |
| Isotype | IgG1, kappa |
| Reactivity | Human |
| Applications | ELISA, FC, IHC |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 970 |
| Uniprot | P32970 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | R.Q. Hintzen, et al, (1994) J Immunol 152: 1762-1773. M.R. Bowman, et al, (1994) J Immunol 152: 1756-1761. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1137-1138.K. Agematsu, et al, (1995) J Immunol 154: 3627-3635 |
| Supplier | ARP |
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