Anti-EBV Early Antigens (Epstein Barr Virus Ea), Monoclonal Antibody
| Product Name | Anti-EBV Early Antigens (Epstein Barr Virus Ea), Monoclonal Antibody |
|---|---|
| Description | Epstein-Barr virus (EBV), also designated human herpesvirus 4 (HHV-4), is a member of the herpesvirus family and is one of the most common human viruses. EBV infects B cells and, though often asymptomatic, it can cause infectious mononucleosis, a disease characterized by fatigue, fever, sore throat and muscle soreness. The EBV-induced early antigens (Ea) are among several antigen complexes that have been identified in EBV-infected cells. The Ea complex is composed of diffuse (Ea-D) and restricted (Ea-R) components. The activity of Ea-D is suppressed during latent infection. BMRF1, the gene that encodes for Ea-D, is closely associated with the gene encoding for EBV DNA polymerase, and Ea-D is essential for the activity of this polymerase. Ea-D forms a complex with EBV DNase and, together, they may play a role in viral replication. |
| Synonyms | EBNA1, EBV nuclear antigen 1, Epstein Barr nuclear antigen 1, Human Herpesvirus 4 (HHV4) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 1108-1. |
| Immunogen | Affinity purified early antigen polypeptides from induced Raji cells precipitated with African BurkittÕs lymphoma sera |
| Isotype | IgG1, kappa |
| Applications | IF |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Epstein, Alan L.: Immunobiochemical characterization with monoclonal antibodies of Epstein-Barr virus-associated early antigens in chemically induced cells. J. Virology 50:372-379, 1984 |
| Supplier | ARP |
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