| Product Name | Anti-GITR / Tnfrsf18 (mouse), Monoclonal Antibody |
|---|---|
| Description | GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+_CD4+_Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-__B activation, and abrogate the inhibitory function of_CD25+_CD4+_Tregs. In vivo_activation of GITR causes development of autoimmune diseases and restores the suppressed immune response. |
| Synonyms | Activation-inducible TNF-related ligand, AITRL, GITRL, Glucocorticoid induced TNFR related protein ligand, Glucocorticoid-induced TNF-related ligand, hGITRL, TL6, TNFSF18, Tumor necrosis factor (ligand) superfamily member 18 |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | DTA-1 |
| Immunogen | Mouse CD25+ CD4+ T cells |
| Isotype | IgG2b, lambda |
| Reactivity | Mouse |
| Applications | FC, IF |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 21936 (Mouse) |
| Uniprot | O35714 (Mouse) |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Stephens GL, et al. 2004. J. Immunol. 173:5008.Tone M, et al. 2003. Proc. Natl. Acad. Sci. USA 100:15059 |
| Supplier | ARP |
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