Product Name | ATG4C Antibody |
---|---|
Description | Rabbit polyclonal antibody to ATG4C |
Synonyms | APG4 autophagy 4 homolog C (S. cerevisiae) antibody; APG4 autophagy 4 homolog C antibody; APG4 C antibody; APG4-C antibody; APG4C antibody; ATG 4C antibody; ATG4 autophagy related 4 homolog C (S. cerevisiae) antibody; ATG4 autophagy related 4 homolog C antibody; Atg4c antibody; ATG4C_HUMAN antibody; AUT (S. cerevisiae) like 1; cysteine endopeptidase antibody; AUT like 1; cysteine endopeptidase (S. cerevisiae) antibody; AUT like 1; cysteine endopeptidase antibody; AUT like 3 cysteine endopeptidase antibody; AUT-like 3 cysteine endopeptidase antibody; AUTL1 antibody; AUTL3 antibody; Autophagin 3 antibody; Autophagin-3 antibody; Autophagy related 4C cysteine peptidase antibody; Autophagy related cysteine endopeptidase 3 antibody; Autophagy related protein 4 homolog C antibody; Autophagy-related cysteine endopeptidase 3 antibody; Autophagy-related protein 4 homolog C antibody; Cysteine protease ATG4C antibody; EC 3.4.22 antibody; FLJ14867 antibody; OTTHUMP00000010715 antibody |
Host | Rabbit |
Clonality | Polyclonal |
Conjugate | Unconjugated |
Immunogen | Recombinant human Cysteine protease ATG4C protein (259-458AA) |
Isotype | IgG |
Target | ATG4C |
Reactivity | Human, Mouse |
Applications | ELISA, IHC, WB |
Form | Liquid |
Diluent Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Uniprot | Q96DT6 |
Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
Background | Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. |
Supplier | Cusabio |
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