| Product Name | BCL2 Antibody |
|---|---|
| Description | A synthesized peptide |
| Synonyms | Apoptosis regulator Bcl-2, BCL2 |
| Clonality | Monoclonal |
| Clone | 2C6 |
| Conjugate | Unconjugated |
| Immunogen | A synthesized peptide |
| Isotype | Rabbit IgG |
| Target | BCL2 |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, FC, IHC, WB |
| Working Dilutions | Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:500 |
| Form | Liquid |
| Diluent Buffer | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | P10415 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). |
| Supplier | Cusabio |
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