BUB1B Antibody, Biotin conjugated

Category: Antibodies
Catalog
CSB-PA002883LD01HU
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Product Name BUB1B Antibody, Biotin conjugated
Description Rabbit polyclonal antibody against BUB1B conjugated to Biotin.
Synonyms Beta homolg of S. cerevisiae BUB 1 antibody; Beta homolg of S. cerevisiae budding uninhibited by benzimidazoles antibody; BUB 1B antibody; BUB1 budding uninhibited by benzimidazoles 1 homolog beta antibody; Bub1A antibody; BUB1B antibody; BUB1B_HUMAN antibody; BUB1beta antibody; BUBR1 antibody; Budding Uninhibited by Benzimidazoles 1 beta antibody; Budding uninhibited by benzimidazoles 1 homolog beta (yeast) antibody; hBUBR1 antibody; MAD3/BUB1 related protein kinase antibody; MAD3/BUB1-related protein kinase antibody; MAD3L antibody; Mitotic checkpoint gene BUB1B antibody; Mitotic checkpoint kinase MAD3L antibody; Mitotic checkpoint serine/threonine protein kinase BUB1 beta antibody; Mitotic checkpoint serine/threonine-protein kinase BUB1 beta antibody; MVA1 antibody; OTTHUMP00000160319 antibody; Protein SSK1 antibody; SSK 1 antibody; SSK1 antibody
Host Rabbit
Clonality Polyclonal
Conjugate Biotin
Immunogen Recombinant human Mitotic checkpoint serine/threonine-protein kinase BUB1 beta protein (230-394AA)
Isotype IgG
Target BUB1B
Reactivity Human
Applications ELISA
Form Liquid
Diluent Buffer Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Uniprot O60566
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Background Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.
Supplier Cusabio

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