| Product Name | CADM1 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to CADM1 |
| Synonyms | BL2 antibody; Cadm1 antibody; CADM1_HUMAN antibody; Cell adhesion molecule 1 antibody; DKFZp686F1789 antibody; IgSF4 antibody; IGSF4A antibody; Immunoglobulin superfamily member 4 antibody; MGC149785 antibody; MGC51880 antibody; NECL-2 antibody; NECL2 antibody; Nectin like 2 antibody; Nectin-like protein 2 antibody; RA175 antibody; SgIGSF antibody; Spermatogenic immunoglobulin superfamily antibody; ST17 antibody; sTSLC 1 antibody; Synaptic cell adhesion molecule antibody; SynCAM antibody; SynCAM1 antibody; TSLC-1 antibody; TSLC1 antibody; Tumor suppressor in lung cancer 1 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthesized peptide derived from C-terminal of human CADM1. |
| Isotype | IgG |
| Target | CADM1 |
| Reactivity | Human, Mouse |
| Applications | ELISA, WB |
| Form | liquid |
| Diluent Buffer | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | Q9BY67 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background |
Mediates homophilic cell-cell adhesion in a Ca2+-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca2+-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly By similarity. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. UniProtKB Q8R5M8 Zhou Y., Biochim. Biophys. Acta 1669:142-154(2005). Ota T., Nat. Genet. 36:40-45(2004). Kuramochi M., Nat. Genet. 27:427-430(2001). |
| Supplier | Cusabio |
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