| Product Name | Cav beta 4 Antibody: ATTO 700 |
|---|---|
| Description | This gene encodes a member of the beta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized (1, 2). . Mouse Anti-Rat Cav beta 4 Monoclonal IgG1 |
| Synonyms | CAB4 Antibody, CACNLB4 Antibody, EA5 Antibody, EJM Antibody, Calcium channel voltage dependent beta 4 subunit Antibody |
| Host | Mouse |
| Clone | S10-7 |
| Immunogen | Synthetic peptide amino acids 458-474 of rat CavB4 |
| Isotype | IgG1 |
| Specificity | Detects ~50kDa. No cross-reactivity against rat Cab Beta1b, Cav beta2a, and Cav betas3 in transfected cells. |
| Reactivity | Hamster, Human, Mouse, Rat |
| Applications | AM, ICC, IF, IHC, IP, WB |
| Form | Purified, in PBS pH7.4, 50% glycerol, 0.09% sodium azide |
| Gene Id | NP_000717.2. 785 |
| Uniprot | O00305 |
| Background |
This gene encodes a member of the beta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized (1, 2). |
| Supplier | Stressmarq Biosciences |
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