| Product Name | CD146 Antibody |
|---|---|
| Description | A synthesized peptide |
| Synonyms | Cell surface glycoprotein MUC18, Cell surface glycoprotein P1H12, Melanoma cell adhesion molecule, Melanoma-associated antigen A32, Melanoma-associated antigen MUC18, S-endo 1 endothelial-associated antigen, CD146, MCAM, MUC18 |
| Clonality | Monoclonal |
| Clone | 8A10 |
| Conjugate | Unconjugated |
| Immunogen | A synthesized peptide |
| Isotype | Rabbit IgG |
| Target | MCAM |
| Reactivity | Human |
| Applications | ELISA, FC, IF, IHC, WB |
| Working Dilutions | Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:500, IF:1:30-1:200 |
| Form | Liquid |
| Diluent Buffer | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | P43121 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. |
| Supplier | Cusabio |
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