| Product Name | [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic polypeptide |
|---|---|
| Description | [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide is a potent and selective peptide agonist for the neuropeptide Y Y5 receptor , with IC50 values for inhibition of neuropeptide Y binding to human Y5, Y1, Y2 and Y4 receptors of 0.24, 530, > 500, and 51 nM respectively, and a Ki at Y5 of 0.1 - 0.15 nM. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide stimulates food intake in vivo. |
| Synonyms | [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]hPP |
| Molecular Weight | 4207.67 Da |
| Target | Neuropeptide Y receptors |
| Amino Acid Sequence | GPSQPTYPGDNATPEQMARYYSALRRYINMAXRQRY-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 313988-89-5 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: X = Aib, Tyr-36 = C-terminal amide |
| References |
Cabrele et al (2000) The first selective agonist for the neuropeptide YY5 receptor increases food intake in rats. J.Biol.Chem. 275 36043 PMID: 10944518Quarta et al (2011) Central administration of NPY or an NPY-Y5 selective agonist increase in vivo extracellular monoamine levels in mesocorticolimbic projecting areas. Neuropharmacology 60(2-3) 328 PMID: 20868698Medeiros and Jackson (2013) Neuropeptide Y Y5-receptor activation on breast cancer cells acts as a paracrine system that stimulates VEGF expression and secretion to promote angiogenesis. Peptides 48 106 PMID: 23932937 Related areasAll peptides >All neuropeptide Y receptor modulators >All appetite regulation research categories > |
| Supplier | Isca Biochemicals Limited |
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