| Product Name | [D-Ala2]-Deltorphin II |
|---|---|
| Description |
[D-Ala2]-Deltorphin II, or deltorphin 2, is a highly selective δ opioid receptor agonist. [D-Ala2]-deltorphin II is antinociceptive in vivo and and approximately equipotent with morphine in producing antinociception in models of pain. The antinociceptive effects of [D-Ala2]-deltorphin II are reversed by δ opioid receptor antagonists, unlike those of morphine. |
| Synonyms | Deltorphin 2 |
| Molecular Weight | 782.89 Da |
| Target | δ Opioid receptors |
| Amino Acid Sequence | YaFEVVG-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 122752-16-3 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: Ala-2 = D-Ala, C-terminal amide |
| References |
Jiang et al (1990) Antinociceptive effects of [D-Ala2]deltorphin II, a highly selective δ agonist in vivo, Life Sciences 47(11) PL43 PMID: 2170791Thomas et al (1997) Structure-activity relationships of a series of [D-Ala2]deltorphin I and II analogues; in vitro blood-brain barrier permeability and stability. J Pharmacol Exp Ther. 281(2) 817 PMID: 9152390Joukal et al (2020) Peripheral Deltorphin II Inhibits Nociceptors Following Nerve Injury. Frontiers in Pharmacology 11 1151 PMID: 32848761 Related areasAll peptides >All δ opioid receptor modulators >All pain research categories > |
| Supplier | Isca Biochemicals Limited |
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