| Product Name | FBXO6 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to FBXO6 |
| Synonyms | F box protein that recognizes sugar chains 2 antibody; F box G domain protein 2 antibody; F box only protein 6 antibody; F box protein 6 antibody; F box protein FBG2 antibody; F box protein Fbx6 antibody; F box/G domain protein 2 antibody; F-box only protein 6 antibody; F-box protein that recognizes sugar chains 2 antibody; F-box/G-domain protein 2 antibody; FBG 2 antibody; FBG2 antibody; FBS 2 antibody; FBS2 antibody; FBX 6 antibody; FBX6 antibody; FBX6_HUMAN antibody; FBXO 6 antibody; FBXO6 antibody; OTTHUMP00000002267 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Recombinant human F-box only protein 6 protein (104-293AA) |
| Isotype | IgG |
| Target | FBXO6 |
| Reactivity | Human |
| Applications | ELISA, IHC, WB |
| Form | Liquid |
| Diluent Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Uniprot | Q9NRD1 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication. |
| Supplier | Cusabio |
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