Human Transfusion transimitted virus antibody (TTV-Ab) ELISA Kit
| Product Name | Human Transfusion transimitted virus antibody (TTV-Ab) ELISA Kit |
|---|---|
| Description | Human Transfusion transimitted virus antibody (TTV-Ab) ELISA Kit has high sensitivity and excellent specificity for detection of Human TTV-Ab. No significant cross-reactivity or interference between Human TTV-Ab and analogues was observed. Exostosin-1 is an endoplasmic reticulum-resident type II transmembrane glycosyltransferase involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type I form of multiple exostoses.By screening a human chondrocyte cDNA library with cosmids that spanned breakpoints on chromosome 8q identified in patients with multiple exostoses type I, Ahn et al. (1995) identified a cDNA encoding a putative 746-amino acid protein with a molecular mass of 86.3 kD. Northern blot analysis detected expression of a 3.4-kb transcript in all tissues tested, with highest levels in liver. The authors noted that the breakpoint region in the EXT1 gene contains 2 identical polypyrimidine tracts (CCCCCCT) that are known to be deletion hotspots, similar to the retinoblastoma gene. This Human Transfusion transimitted virus antibody (TTV-Ab) ELISA Kit employs the competitive enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with an antibody specific to TTV-Ab. Standards or samples are then added to the appropriate microtiter plate wells with a Horseradish Peroxidase (HRP)-conjugated TTV-Ab and incubated. The competitive inhibition reaction is launched between with HRP labeled TTV-Ab and unlabeled TTV-Ab with the antibody. A substrate solution is added to the wells and the color develops in opposite to the amount of TTV-Ab in the sample. The color development is stopped and the intensity of the color is measured. |
| Synonyms | TTV-Ab, hepatitis H virus |
| Method | Sandwich ELISA |
| Detection Range | Please inquire |
| Sensitivity | Please inquire |
| Reactivity | Human |
| Sample Types | Cell culture supernatants, Serum, Plasma, Other biological fluids |
| Storage | 2-8°C |
| Background | Exostosin-1 is an endoplasmic reticulum-resident type II transmembrane glycosyltransferase involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type I form of multiple exostoses.By screening a human chondrocyte cDNA library with cosmids that spanned breakpoints on chromosome 8q identified in patients with multiple exostoses type I, Ahn et al. (1995) identified a cDNA encoding a putative 746-amino acid protein with a molecular mass of 86.3 kD. Northern blot analysis detected expression of a 3.4-kb transcript in all tissues tested, with highest levels in liver. The authors noted that the breakpoint region in the EXT1 gene contains 2 identical polypyrimidine tracts (CCCCCCT) that are known to be deletion hotspots, similar to the retinoblastoma gene. |
| Supplier | Abbkine |
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