| Product Name | KDM3B Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to KDM3B |
| Synonyms | 5qNCA antibody; C5orf7 antibody; JHDM2B antibody; JmjC domain containing histone demethylation protein 2B antibody; JmjC domain-containing histone demethylation protein 2B antibody; jmjd1b antibody; Jumonji domain containing 1B antibody; Jumonji domain containing protein 1B antibody; Jumonji domain-containing protein 1B antibody; KDM3B antibody; KDM3B_HUMAN antibody; KIAA1082 antibody; Lysine (K) specific demethylase 3B antibody; Lysine-specific demethylase 3B antibody; NET22 antibody; Nuclear protein 5qNCA antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Fusion protein of human KDM3B |
| Isotype | IgG |
| Target | KDM3B |
| Reactivity | Human, Mouse |
| Applications | ELISA, IHC, WB |
| Form | Liquid |
| Diluent Buffer | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Uniprot | Q7LBC6 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | JMJD1B (jumonji domain containing 1B), also known as KDM3B, 5qNCA (5q Nuclear Co-Activator) or C5orf7, is a member of the JHDM2 histone demethylase family of proteins. Expressed in a wide variety of tissues, JMJD1B localizes to the nucleus and contains one JMJC domain and a C-terminal zinc finger motif. JMJD1B functions as a histone demethylase and, using iron as a cofactor, demethylates lysine-9 of Histone H3. This suggests that JMJD1B plays a central role in the histone code. The gene encoding human JMJD1B is located within the 5q region of the genome that is often deleted in myeloid leukemias and myelodysplasias. This implies that JMJD1B may function as a tumor suppressor of myeloid leukemia. Eptopic expression of JMJD1B exhibits growth suppressive activities, further supporting a role for JMJD1B in tumor suppression. |
| Supplier | Cusabio |
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