| Product Name | L3MBTL1 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to L3MBTL1 |
| Synonyms | dJ138B7.3 antibody; H-L(3)MBT antibody; H-l(3)mbt protein antibody; KIAA0681 antibody; L(3)mbt protein homolog antibody; L(3)mbt-like antibody; L3MBT antibody; L3MBTL antibody; L3MBTL1 antibody; Lethal (3) malignant brain tumor l(3 antibody; Lethal(3)malignant brain tumor-like protein 1 antibody; LMBL1_HUMAN antibody; RGD1307316 antibody; ZC2HC3 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Recombinant human Lethal (3)malignant brain tumor-like protein 1 protein (513-752AA) |
| Isotype | IgG |
| Target | L3MBTL1 |
| Reactivity | Human |
| Applications | ELISA, IHC |
| Form | Liquid |
| Diluent Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Uniprot | Q9Y468 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. |
| Supplier | Cusabio |
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