| Product Name | [Leu144, Arg147]-PLP (139-151) |
|---|---|
| Description | [Leu144, Arg147]-PLP (139-151) is an analogue of PLP (139-151) which can act as a T-cell receptor antagonist, able to prevent development of the autoimmune disease model experimental allergic encephalomyelitis (EAE). [Leu144, Arg147]-PLP (139-151 prevents EAE when co-administered with native PLP(139–151) and can limit progression of EAE if given early after the onset of disease in mice. |
| Synonyms | H-HSLGKLLGRPDKF-OH, 188859-65-6, Arg147]-PLP (139-151), EAE, HSLGKLLGRPDKF, NR-040, NR040, T-cell receptor antagonist, [Leu144, autoimmune disease model experimental allergic encephalomyelitis |
| Molecular Weight | 1467.7 Da |
| Target | Epitopes |
| Amino Acid Sequence | HSLGKLLGRPDKF |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Cas Number | 188859-65-6 |
| Storage | Store desiccated, frozen and in the dark |
| Notes | Modifications: None |
| References |
Ruiz et al (1999) Suppressive Immunization with DNA Encoding a Self-Peptide Prevents Autoimmune Disease: Modulation of T Cell Costimulation J. Immunol. (1999) 162(6) 3336 PMID: 10092787Anderton (2001) Peptide-based immunotherapy of autoimmunity: a path of puzzles, paradoxes and possibilities. Immunology 104(4) 367 PMID: 11899421Potolicchio et al (2005) Conformational Variation of Surface Class II MHC Proteins during Myeloid Dendritic Cell Differentiation Accompanies Structural Changes in Lysosomal MIIC. J. Immunol. 175 4935 PMID: 16210595 Related dataAll myelin peptides >All immunology research areas > |
| Supplier | Isca Biochemicals Limited |
All Research Products are sold for laboratory RESEARCH USE ONLY and ARE NOT TO BE USED FOR HUMAN OR ANIMAL THERAPEUTIC OR DIAGNOSTIC APPLICATIONS. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. ARP American Research Products, Inc. does not submit its products for regulatory review by any government body or other organization, and we do not validate them for clinical, therapeutic or diagnostic use, or for safety and effectiveness. You are solely responsible for making sure that the way you use the products complies with applicable laws, regulations and governmental policies and for obtaining all necessary approvals, intellectual property rights, licenses and permissions that you may need related to your use. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process. ARP American Research Products, Inc. disclaims any and all representations or warranties of any kind whatsoever, express or implied, including without limitation any implied warranties of merchantability or fitness for a particular purpose, of non-infringement, or regarding results obtained through the use of any product, whether arising from a statute or otherwise in law or from a course of performance, dealing or usage of trade.
