| Product Name | [Leu31,Pro34]-Neuropeptide Y (human, rat) |
|---|---|
| Description |
[Leu31,Pro34]-Neuropeptide Y (human, rat) is a high affinity neuropeptide Y Y1 receptor agonist with a Ki of 0.39 nM, and also some affinity for Y4 and Y5 receptors. [Leu31,Pro34]-NPY microinjected into the periaqueductal gray produces both analgesic and anxiolytic effects in rats, and intrathecal administration of [Leu31,Pro34]-Neuropeptide Y (human, rat) can attenuate itch behaviour in mice. |
| Synonyms | [Leu31,Pro34]-NPY (human) |
| Molecular Weight | 4241 Da |
| Target | Neuropeptide Y receptors |
| Amino Acid Sequence | YPSKPDNPGEDAPAEDMARYYSALRHYINLLTRPRY-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 132699-73-1 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: C-terminal amide |
| References |
Fuhlendorff et al (1990) [Leu31, Pro34]Neuropeptide Y: a specific Y1 receptor agonist. Proc.Natl.Acad.Sci.U.S.A. 87 182 PMID: 2153286Vázquez-León (2017) Analgesic and anxiolytic effects of [Leu31,Pro34]-neuropeptide Y microinjected into the periaqueductal gray in rats, Neuropeptides 66 81 PMID: 29042065Gao et al (2018) The Neuropeptide Y System Regulates Both Mechanical and Histaminergic Itch. J. Investigative Dermatology 138(11) 2405 PMID: 29803641 Related areasAll peptides >All neuropeptide Y receptor modulators >All neuroscience research categories >All pain research categories > |
| Supplier | Isca Biochemicals Limited |
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