| Product Name | [Leu5]-Enkephalin |
|---|---|
| Description |
[Leu5]-Enkephalin is an endogenous opioid peptide neurotransmitter that is found in the brains of many animals including humans. [Leu5]-Enkephalin is one of the two forms of enkephalin; the other being met-enkephalin. The tyrosine residue at position 1 is analogous to the 3-hydroxyl group on morphine and [Leu5]-enkephalin acts as an agonist at both μ- and δ-opioid receptors, with greater preference for δ and little to no effect on the κ-opioid receptor. |
| Synonyms | ICI 114740, Dynorphin-(1-5), Leu-enkephalin, Leu5-enkephalin |
| Molecular Weight | 555.63 Da |
| Target | δ Opioid receptors,μ Opioid receptors |
| Amino Acid Sequence | YGGFL |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 58822-25-6 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Meunier et al (1977) Binding of Leu5-enkephalin and Met5-enkephalin to a particulate fraction from rat cerebrum. FEBS Lett. 77 209 PMID: 862920Porreca et al (1990) Modulation of morphine antinociception by peripheral [Leu5]enkephalin: a synergistic interaction. Eur J Pharmacol. 179(3) 463 PMID: 2364995Cheng et al (1996) Immunolabeling of mu opioid receptors in the rat nucleus of the solitary tract: extrasynaptic plasmalemmal localization and association with Leu5-enkephalin. J. Comp. Neurol. 371 522 PMID: 8841907PubChem Related areas All peptides >All δ opioid receptor modulators >All μ opioid receptor modulators >All pain research categories > |
| Supplier | Isca Biochemicals Limited |
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