| Product Name | mStab1-1.26, InVivoPure |
|---|---|
| Description | mStab1-1.26, InVivoPure+ is a mouse monoclonal antibody against mouse Stabilin-1 (UniProt entry: Q8R4Y4), also known as Clever-1 or FEEL-1. Stabilin-1 is a scavenger receptor expressed by sinusoidal endothelial cells (ECs) in the liver, lymph nodes, spleen, and bone marrow [1]. Stabilin-1 is expressed in human breast cancer and supports tumor growth [2]. It is found on subset of macrophages that mediate tissue homeostasis and is involved in liver fibrosis [3]. mStab1-1.26 or mStabilin-1 (clone 1.26) is first mentioned by Schledzewski et al. (2006) [4]. To generate the antibody, a recombinant mouse stabilin-1 fragment (residues 1–710 of Q8R4Y4) fused to mouse IgG2b-Fc was purified from stably-transfected HEK293 cells and used to immunize stabilin-1 knockout mice. mStab1-1.26 recognizes stabilin-1 in rat and mouse. The antibody is produced exclusively under serum-free conditions from hybridoma and purified through one-step purification with Protein-G affinity chromatography. |
| Synonyms | STABILIN-1, FEX1, SCARH2, FEEL-1, FEEL1, FELE-1, CLEVER-1, mouse stab1 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 1.26 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant mouse Stabilin-1 fragment from HEK 293 (residues 1–710 of Q8R4Y4, fused to mouse-IgG2b-Fc |
| Isotype | IgG1 κ |
| Target | Stabilin-1 |
| Reactivity | Mouse, Rat |
| Applications | In vivo |
| Form | Liquid, PBS, pH 7.4, 0.2 μm sterile filtered |
| Concentration | ≥ 1.00 mg/ mL |
| Purity | ≥ 90 % (CGE, reducing conditions) Endotoxin level ≤ 2 EU/mg |
| Uniprot | Q8R4Y4 |
| Supplier | Invivo Biotech |
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