[Pyr1]-Apelin 13

Category: Bioreagents
Catalog
AR-020
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Product Name [Pyr1]-Apelin 13
Description [Pyr1]-Apelin 13 or [pGlu1]-apelin-13 is a highly potent pyroglutamyl form of apelin 13 which acts as the endogenous ligand for the apelin APJ receptor, with an EC50 of 0.37 nM. [Pyr1]-Apelin 13 is the predominant isoform detected in human heart and plasma and acts as a potent inotropic agent and vasodilator.
Synonyms [Pyr1]-Apelin 13, [pGlu1]-apelin-13
Molecular Weight 1533.8 Da
Target Apelin receptors
Amino Acid Sequence XRPRLSHKGPMPF
Form Freeze dried solid
Purity >95% by HPLC
Cas Number 217082-60-5
Storage Store dry, frozen and in the dark
Notes Modifications: X is pGlu
References Tatemoto et al (1998) Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem.Biophys.Res.Comm. 251 471 PMID: 9792798Kleinz et al (2005) Emerging roles of apelin in biology and medicine. Pharmacol.Ther. 107 198 PMID: 15907343Yang et al (2015) Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system. TiPS 36(9) 560 PMID: 26143239Guide to pharmacology - [Pyr1]-Apelin 13
Related areas
All peptides >All apelin receptor modulators >All cardiovascular research categories >
Supplier Isca Biochemicals Limited

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