| Product Name | RNF128 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to RNF128 |
| Synonyms | E3 ubiquitin protein ligase RNF128 antibody; E3 ubiquitin-protein ligase RNF128 antibody; FLJ23516 antibody; Gene related to anergy in lymphocytes protein antibody; GRAIL antibody; RING finger protein 128 antibody; RN128_HUMAN antibody; RNF128 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Recombinant human E3 ubiquitin-protein ligase RNF128 protein (229-400AA) |
| Isotype | IgG |
| Target | RNF128 |
| Reactivity | Human, Mouse |
| Applications | ELISA, IF, WB |
| Form | Liquid |
| Diluent Buffer | Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Uniprot | Q8TEB7 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals. |
| Supplier | Cusabio |
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