| Product Name | UBE2O Antibody, HRP conjugated |
|---|---|
| Description | Rabbit polyclonal antibody against UBE2O conjugated to HRP |
| Synonyms | E2 230K antibody; EC=6.3.2.19 antibody; FLJ12878 antibody; KIAA1734 antibody; Likely Ortholog of Mouse Ubiquitin Conjugating Enzyme antibody; RP23 193A16.5 antibody; UBE2O antibody; UBE2O_HUMAN antibody; Ubiquitin carrier protein O antibody; Ubiquitin conjugating enzyme E2 O antibody; Ubiquitin conjugating enzyme E2 of 230 kDa antibody; ubiquitin conjugating enzyme E2O antibody; Ubiquitin protein ligase O antibody; Ubiquitin-conjugating enzyme E2 O antibody; Ubiquitin-conjugating enzyme E2 of 230 kDa antibody; Ubiquitin-conjugating enzyme E2-230K antibody; Ubiquitin-protein ligase O antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | HRP |
| Immunogen | Recombinant human (E3-independent) E2 ubiquitin-conjugating enzyme protein (10-277AA) |
| Isotype | IgG |
| Target | UBE2O |
| Reactivity | Human |
| Applications | ELISA |
| Form | Liquid |
| Diluent Buffer | Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Uniprot | Q9C0C9 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853). |
| Supplier | Cusabio |
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