| Product Name | VAMP-1/2/3 Polyclonal Antibody |
|---|---|
| Description | Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by VAMP1 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. VAMP1 (Vesicle Associated Membrane Protein 1) is a Protein Coding gene. Diseases associated with VAMP1 include Spastic Ataxia 1, Autosomal Dominant and Spastic Ataxia 1. Among its related pathways are Uptake and actions of bacterial toxins and HIV Life Cycle. GO annotations related to this gene include SNARE binding and SNAP receptor activity. An important paralog of this gene is VAMP2. The protein encoded by VAMP2 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. VAMP2 (Vesicle Associated Membrane Protein 2) is a Protein Coding gene. Diseases associated with VAMP2 include Tetanus and Infant Botulism. Among its related pathways are Clathrin derived vesicle budding and Uptake and actions of bacterial toxins. GO annotations related to this gene include calmodulin binding and syntaxin binding. An important paralog of this gene is ENSG00000263620. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP3 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation.VAMP3 (Vesicle Associated Membrane Protein 3) is a Protein Coding gene. Diseases associated with VAMP3 include Tetanus and Primary Bacterial Infectious Disease. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include SNARE binding and syntaxin-1 binding. An important paralog of this gene is VAMP2. |
| Synonyms | VAMP1, SYB1, Vesicle-associated membrane protein 1, VAMP-1, Synaptobrevin-1, VAMP2, SYB2, Vesicle-associated membrane protein 2, VAMP-2, Synaptobrevin-2, VAMP3, SYB3, Vesicle-associated membrane protein 3, VAMP-3, Cellubrevin, CEB, Synaptob |
| Host | Rabbit |
| Immunogen | Synthesized peptide derived from the Internal region of human VAMP-1/2/3. |
| Isotype | IgG |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IHC, WB |
| Form | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4 |
| Uniprot | P23763/P63027/Q15836 |
| Background |
Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by VAMP1 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. VAMP1 (Vesicle Associated Membrane Protein 1) is a Protein Coding gene. Diseases associated with VAMP1 include Spastic Ataxia 1, Autosomal Dominant and Spastic Ataxia 1. Among its related pathways are Uptake and actions of bacterial toxins and HIV Life Cycle. GO annotations related to this gene include SNARE binding and SNAP receptor activity. An important paralog of this gene is VAMP2. The protein encoded by VAMP2 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. VAMP2 (Vesicle Associated Membrane Protein 2) is a Protein Coding gene. Diseases associated with VAMP2 include Tetanus and Infant Botulism. Among its related pathways are Clathrin derived vesicle budding and Uptake and actions of bacterial toxins. GO annotations related to this gene include calmodulin binding and syntaxin binding. An important paralog of this gene is ENSG00000263620. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP3 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation.VAMP3 (Vesicle Associated Membrane Protein 3) is a Protein Coding gene. Diseases associated with VAMP3 include Tetanus and Primary Bacterial Infectious Disease. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include SNARE binding and syntaxin-1 binding. An important paralog of this gene is VAMP2. |
| Supplier | Elabscience |
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